... stability.AbbreviationsALLN, N-acetyl-L-leucyl-L-leucyl-L-norleucinal; GAP, GTPase activating protein; G protein, heterotrimeric guanine nucleotide-binding protein;GPCR, G protein-coupled receptor; GRK, G protein-coupled ... RGS domain in the amino-terminus of Gprotein-coupled receptor kinase 2 inhibits Gq-mediatedsignaling. Int J Mol Med 5, 335–340.20 Chen CA & Manning DR (2001) Regulation of G pro-teins by ... with 60 and 40% of the pro-tein remaining at 3 and 6 h, respectively, both for the ligand-activated and nonactivated Gaq. Adding newmedia containing 10 lm carbachol every 30 min during the chase...