Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing docx

... that includes a DNA-binding domain, a ligand-binding domain and a transactivation domain. The DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding ... ª 2010 FEBS MINIREVIEW Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing Khairul I. Ansari and Subhrangsu S. Mandal Departm...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: roles in human malignancies and potential therapy pdf

... proteins. Thus, the MEN1 ⁄ LEDGF-interacting domain linked to DNA-binding domains (AT-hook and MT domain) becomes disconnected from the PHD domains, the FYRN domain, the transactivating domain, ... different signaling pathways, for example, protein kinase C, protein kinase A, RAS ⁄ RAF, WNT-, phosphatidylinositol 3-kinase and Hedgehog, and thus affects metabolism, the cell cycle, gen...
Ngày tải lên : 16/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human pptx

... clinical trials in epigenetic therapy. Rev Recent Clin Trials 1, 169– 182. 162 Ansari KI & Mandal SS (2010) Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. ... (2000) A chromatin remodelling complex involved in transcrip- tion and DNA processing. Nature 406, 541–544. 24 Conaway RC & Conaway JW (2009) The INO80 chro...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

Tài liệu Báo cáo khoa học: Mixed lineage leukemia: a structure–function perspective of the MLL1 protein ppt

... S-adenosyl-homocysteine; BD, bromo domain; CBP, CREB-binding protein; CREB, cAMP response element-binding; H3K4, histone H3 lysine 4; HMT, histone methyltransferase; MLL1, mixed lineage leukemia protein-1; ... required for the structural integrity of the protein, as mutation of any of the cysteine residues involved in zinc coordina- tion results in protein unfolding [22]. The structur...
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Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

Tài liệu Báo cáo khoa học: Mixed lineage leukemia histone methylases play critical roles in estrogen-mediated regulation of HOXC13 docx

... binding profiles in a time-dependent manner in ERE1 and ERE2 (Fig. 5B). In agreement with the above findings, binding of ERa and ERb was increased in both ERE1 and ERE2 in the presence of E2. Interestingly, ... Binding of ERa and ERb was increased in both ERE1 and ERE2 of the HOXC13 promoter (Fig. 5A, lanes 1–4). The levels of E2-induced binding of ERa and ERb were highe...
Ngày tải lên : 18/02/2014, 14:20
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Tài liệu Báo cáo khoa học: What MAN1 does to the Smads TGFb/BMP signaling and the nuclear envelope Luiza Bengtsson pdf

Tài liệu Báo cáo khoa học: What MAN1 does to the Smads TGFb/BMP signaling and the nuclear envelope Luiza Bengtsson pdf

... Prelamin A and BAF are also binding partners of emerin [39]. Interestingly, the N-terminus of human MAN1 binds the human emerin itself (Fig. 1; [8]). Emerin is an integral membrane protein and ... for binding to emerin in vitro. J Biol Chem 278, 6969–6975. 8 Mansharamani M & Wilson KL (2005) Nuclear mem- brane protein MAN1: Direct binding to emerin in vitro and two modes of bind...
Ngày tải lên : 19/02/2014, 02:20
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Tài liệu Báo cáo khoa học: Modulation of oat arginine decarboxylase gene expression and genome organization in transgenic Trypanosoma cruzi epimastigotes docx

Tài liệu Báo cáo khoa học: Modulation of oat arginine decarboxylase gene expression and genome organization in transgenic Trypanosoma cruzi epimastigotes docx

... con- taining DNA spots (5 lg each) corresponding to inter- nal fragments of ADC or cruzipain genes. The latter (used as a control) is a housekeeping gene that encodes the main cysteine proteinase ... Analysis of a cDNA- encoding arginine decarboxylase from oat reveals simi- larity to the Escherichia coli arginine decarboxylse and evidence of protein processing. Mol Gen Genet 224, 431–436...
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Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt

Tài liệu Báo cáo khoa học: Mixed-type noncompetitive inhibition of anthrax lethal factor protease by aminoglycosides ppt

... enzyme–inhib- itor binding interaction. log K ðappÞ i ¼ log K Ã þ 1: 18Z E Z L ffiffi I p ð7Þ Discussion In this study we have determined that neomycin B and its close structural analog, neamine, are mixed- type noncompetitive ... manifes- ted in Figs 3 and 4. Note that the Lineweaver–Burk plot in Fig. 4 is distinctly nonlinear. The results are illustrated in Fig. 5, in which the w...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... shown that interactions between KCs and endotoxin comprise the initiating event lead- ing to hepatotoxicity in liver injury, including endotox- emia and ischemia ⁄ reperfusion injury [14]. In our studies, ... factor-a and interleukin-6, and increased hepatic mRNA levels of tumor necrosis factor-a and interleukin-6 were decreased by depletion of KCs. Our findings suggest that ab...
Ngày tải lên : 14/02/2014, 18:20
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Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

Tài liệu Báo cáo khoa học: Transient RNA–protein interactions in RNA folding docx

... of opening of the initial double strand and the annealing of the new duplex finally results in either the replacement of the original strand or the expulsion of the invading strand, according to ... unwinding. High-resolution X-ray struc- tures have given insights into the mechanism(s) of DEAD-box helicases. The binding sites for double- stranded RNA and ATP overlap, resulting in coupl...
Ngày tải lên : 14/02/2014, 19:20
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