... antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid Bilal A. Azakir, Guillaume Desrochers and Annie AngersDe´partement ... tBid levels and the ubiquitin ligase activity of Itch. In this study, we first examined the ability of Itch tointeract with Bid and tBid. We found that Itch specifi-cally interacts with tBid, but ... activation of the epidermal growth factor (EGF) pathway. Here, we provide evidence that tBid is asubstrate of the ubiquitin ligase Itch, which can specifically interact with and ubiquitinate tBid,...