Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
Tài liệu Báo cáo khoa học: 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent apoptotic pathway doc
... ª 2009 The Authors Journal compilation ª 2009 FEBS 3T3-L1 adipocyte apoptosis induced by thiazolidinediones is peroxisome proliferator-activated receptor-c-dependent and mediated by the caspase-3-dependent ... ago-nist -induced apoptosis [26,27]. In the present study, weinvestigated PPARc agonist -induced adipocyte apopto-sis by using 3T3-L1 adipocytes and rat primary adipo-cytes. Adipocyte apoptosis ... promote apoptosis in adipocytes through aPPARc-dependent pathway. This apoptosis is mediated by the inhibitionof Akt-1, which decreases Bad phosphorylation and activates the mito-chondrial apoptotic...
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Tài liệu Báo cáo khoa học: A DExD⁄ H box RNA helicase is important for K+ deprivation responses and tolerance in Arabidopsis thaliana docx
... expressed in the vascular tissues, such as the midrib of the cotyledon, the hypocotyl, and the rootvasculature (Fig. 2E), and is upregulated by 100 lmK+(low-K+stress) and downregulated by 100 ... responses, and in the ABA sig-naling and stress -induced ABA biosynthetic pathways,respectively, in Arabidopsis [42–44]. Further studiesrevealed that CBL1 and CBL9 functioned in Arabid-opsis as the ... that the expression of AtHELPS,anArabidopsis DExD ⁄ H box RNA helicasegene, was induced by low-K+, zeatin and cold treatments, and downregu-lated by high-K+stress. To further investigate the...
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Tài liệu Báo cáo khoa học: An anthrax lethal factor mutant that is defective at causing pyroptosis retains proapoptotic activity pdf
... cells, the mutant was able toefficiently kill these cells. These data are consistentwith the notion that induction of pyroptosis and apop-tosis by LF occurs through the cleavage of distinctsubstrates.Results ... others. Collectively, theseeffects dampen the innate and adaptive immune systems to allow Bacillusanthracis to survive and proliferate in the mammalian host. The diverseeffects caused by the ... apoptosis. It is unclear why the mutant is defec-tive at causing pyroptosis, but it is presumably becauseLF-K518E ⁄ E682G has a diminished capacity to cleavea substrate that is involved in the...
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Tài liệu Báo cáo khoa học: The plasminogen activator inhibitor 2 transcript is destabilized via a multi-component 3¢ UTR localized adenylate and uridylate-rich instability element in an analogous manner to cytokines and oncogenes pdf
... SJS260, and the creationof the ARE II ⁄ ARE IV double mutant used primers SJS261 and SJS262. The mutagenesis of ARE I and III introducedHindIII restriction sites and so the creation of the pTET-GLO3¢ ... of the ARE I-AUUUA and ARE III-AUUUAsequences used primers SJS172 and SJS173, and SJS174 and SJS175, respectively. Mutation of the atypical AU-richsequence used primers SJS259 and SJS260, and ... of the PAI-2 3¢ UTR were generated viaoverlap extension PCR mutagenesis [57] using SJS133 and SJS134 as the external primers and the constructs pTET-GLOPAI)2 and pTETGLOARE II-MUTas the...
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Tài liệu Báo cáo khoa học: parDtoxin–antitoxin system of plasmid R1 – basic contributions, biotechnological applications and relationships with closely-related toxin–antitoxin systems ppt
... modulate the levels of these proteins: these include the coupling of the toxin to the antitoxin synthesis and the limited degradation of the polycistronic parD mes-senger, which gives rise to ... on the one hand enhances the fluorescence of the internal Trpresidue of the toxin, indicating a local distortion in the structure and, on the other hand, inactivates growthinhibition by the ... system: the antitoxin Sok is an unstable antisense RNA and the Hok is a transmembrane toxic protein. The identity between the parD–pem and chpA–mazEF systems or their proteins is indicatedin parenthesis.E....
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Tài liệu Báo cáo khoa học: Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT–MIM interaction pptx
... for GST and GST-fused proteins (GST–IST1, GST–IST1MIM, GST–IST1MIML326D,L353A, GST–CHMP6NT, GST–pHis and GST–MIT–pHis). Expressionof GST–IST1, GST–IST1MIM and GST–IST1L326D,L353Awas induced ... notenhance the autolysis of mGFP–calpain 7 in culturedcells. On the other hand, overexpression of FLAG–IST1DMIM1,2suppressed the autolysis. This observationmight be explained by regarding IST1 ... RNA -mediated knockdown effects on the endocytic pathway are not evident, IST1 is requiredfor efficient cytokinesis in HeLa cells [32,33]. IST1 and Ist1 associate with CHMP1 ⁄ Did2 to regulate the...
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Tài liệu Báo cáo khoa học: Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression ppt
... shock. This is achieved by HSF1 and the his-tone deacetylases HDAC1 and HDAC2 [77]. In heat-shocked cells, HSF1 binds to HDAC1 and HDAC2, and their histone-deacetylase activities increase. The heat -induced ... com-plex, the third helix of the DBD is docked into the major groove, approximately perpendicular to the heli-cal axis of the DNA. The evolutionarily conservedarginine residue in this recognition ... (H1, H2 and H3), four b-sheets (S1, S2, S3 and S4), a ‘turn’of the helix-turn-helix motif and a disordered loop referred to as a ‘wing’. The linker region connects between the DBD and the HR-A...
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Tài liệu Báo cáo khoa học: The Saccharomyces cerevisiae vacuolar acid trehalase is targeted at the cell surface for its physiological function docx
... ATH1_3 and ATH1_4) usingATH1_1 and ATH1_4 as external primers. This final HA-tagged PCR fragment was cloned into the pGEM-T-easyvector and was then excised by SnaBI ⁄ AgeI to replace the SnaBI ... targeting. Together, theseresults confirmed that trehalase in the vacuole is likelyprompted to partial degradation and is not requiredfor cell growth on trehalose. The TM domain is indispensable ... between these glycolytic enzymes and S. cerevisiaeAth1 is the lack of a classical secretion sequence. How-ever, because Ath1 is not a cytosolic protein, thesemodes of secretion remain unknown. By...
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Tài liệu Báo cáo khoa học: The miRNA-192 ⁄194 cluster regulates the Period gene family and the circadian clock doc
... post-transcriptionalcontrol exerted by miRNAs.miRNAs and the circadian cyclemiR-219 is capable of shortening the circadian period by 10–20 min [12]. The exact mechanism by whichthis miRNA is able to alter the circadian ... experiments, these mutated 3¢UTRs were com-pletely refractory to regulation by the miR-192 ⁄ 194cluster, indicating the direct suppression of Per1, 2 and 3 by these miRNAs (Fig. 3B–D). Together, these ... The miRNA-192⁄194 cluster regulates the Period genefamily and the circadian clockRemco Nagel1, Linda Clijsters1 and Reuven Agami1,21 Division of Gene Regulation, The Netherlands...
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Tài liệu Báo cáo khoa học: Molecular characterization of Arabidopsis thaliana PUF proteins – binding specificity and target candidates doc
... is not the natural RNA target inArabidopsis, the Box B sequence should mimic the authentic Arabidopsis targets. On the other hand,APUM-7 was unable to bind to NRE, possibly as aresult of the ... all of them (sense and antisense) bound to baitspecifically, suggesting the existence of a consensusmotif within these 63 distinct transcripts recognized by APUM-2. We therefore analyzed these ... abolishbinding of APUM-2 to NRE.To evaluate these hypotheses, we tested the interactionof APUM-2 ⁄ N fi H (APUM-2 with the Asp fi HisABCDEFig. 3. Interaction analysis between APUM and the...
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Từ khóa: báo cáo khoa học tài liệu báo cáo tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEQuản lý hoạt động học tập của học sinh theo hướng phát triển kỹ năng học tập hợp tác tại các trường phổ thông dân tộc bán trú huyện ba chẽ, tỉnh quảng ninhPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ