... in the human genome. In addi-tion, VEGF-E encoded in the Orf virus binds and activates only VEGFR-2. Anti-(VEGF-A)IgG and aptamer, as well as VEGFR tyrosinekinase inhibitors (multikinase inhibitors) ... VEGF-B + ⁄ ) or + ⁄ + mice; (c)the VEGF-B receptor, VEGFR-1 (Flt-1), is expressed in astrocytes and motor neurons after injury, and using VEGFR-1 (flt-1) TK) ⁄ ) mice, which are de - cient in ... VEGF-recep-tor-1 and its ligand VEGF-B in motor neuron degenera-tion. J Neurosci 28, 10451–10459.21 Hiratsuka S, Minowa O, Kuno J, Noda T & ShibuyaM (1998) Flt-1 lacking the tyrosine kinase...