Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... 2010 The Authors Journal compilation ª 2010 FEBS Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver ... constitutes the initiating event in the process of lipotoxicity. Stearate has to be activated in order to be toxic The first enzyme involved in metabolism of FFAs aftertheir uptake into liver cells is the ... of a pool of oversaturated inter-mediates, represents the key initiating event in the mechanism of saturated fatty acid-induced lipotoxicity. AbbreviationsACS, long-chain acyl-CoA synthetase;...
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Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx
... [22]. ROS indirectly reduced the activity of selected isoforms of CYP by inducing phosphorylation of the isoforms [23]. Activated KCs cause oxidativestress on the surrounding tissue, releasing largeamounts ... cytokines and liver injury [13].Therefore, the present study aimed to elucidate the role of KCs in the regulation of CYP isoform activitiesand gene expression profiles, partly by investigating the ... liver, is primarily involved in the oxidative metabolism of xenobiotics and is capable of the metabolic activation of numerous procarcino-gens, including aflatoxin B1 [21]. In the present study,CYP1A1...
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Tài liệu Báo cáo khoa học: Role of ceramide kinase in peroxisome proliferatoractivated receptor beta-induced cell survival of mouse keratinocytes ppt
... in skin barrier disruption(Fig. 1A). PPARb mRNA expression was determined in keratinocytes isolated from the epidermal layer of these skins, and was found to be significantly increased in skin ... and increases CerK activity in SP1 cells To investigate the role of CerK and its regulation of Cer levels in the effect of PPARb activation on cellsurvival, the expression of CERK mRNA in SP1 cells treated ... containing putative CERK-PPRE wasanalyzed by PCR. In the ChIP DNA obtained with the anti-PPARb IgG, the amount of DNA containingputative CERK-PPRE was significantly greater in the chromatin of cells...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... of alternative promoters in DNASE1 results in no generation of protein isoforms. The 5¢-UTR of eukaryotic mRNA in uences the initi-ation step of protein synthesis and thereby in partdetermines ... respectively. Con-ditions for these amplifications were 95 °C for 9 min, 37cycles of 94 °C for 1 min, 65 °C for 1 min, and 72 °C for 2 min, followed by incubation at 72 °C for 10 min. The PCRproducts ... exon 2 includes the translation initiationcodon (ATG) and the first exon is believed to includeonly the 5¢-UTR of the mRNA [15,16]. However, com-parison of the sequence of the 5¢-UTR of human...
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Tài liệu Báo cáo khoa học: Motion of the Ca2+ -pump captured ppt
... Histograms of the height differences between the top of SERCA and the surface of the membrane. Statistical section analy-ses of SERCA were performed with the data obtained in the pres-ence of ... ATPhydrolysis of SERCA linearly increased with ATPconcentrations of 1 lm [26]. The lifetime of the elevated conformation (i.e. peakwidth) in the presence of both ATP and Ca2+wasmeasured in the single ... elevation value is very similar to the heightdifference between the E1Ca2+form [14], in which the N-domain is widely separated from the A-domainand P-domain, and the other compacted forms of SERCA...
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Tài liệu Báo cáo khoa học: Mechanisms of amyloid fibril formation – focus on domain-swapping doc
... by the proline in the cis confor-mation.Indirectly, we have confirmed that proline isomeriza-tion is at the root of the slow conformational changecoupled to tetramerization by measuring the ... dependence of the kinetics [123]. The value for the activation energy of 28 ± 3 kcalÆmol)1observed for the P79S mutant tetramer formation is consistent with the contribution of one proline isomerization ... amechanism in which each protein molecule swaps adomain into the neighboring molecule along the grow-ing fibril. By designing disulfide bonds that form onlyat the domain-swapped dimer interface, they...
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Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... 1B shows the patternseen after the development of the blot. With increase in time of incubation, the intensity of the band for the monomeric protein decreased, whereas the bands for the higher ... Nota-bly, in the presence of the neurotoxin, there was adelay in the lag time for fibrillation. The lag timeincreased from 74.9 h in case of a -synuclein alone to86.8 and 93.6 h in the presence of ... solid line), in the presence of 100 lM neurotoxin (•, dotted line), in the presence of 200 lM neurotoxin ( , dottedline) and in the presence of neurotoxin and50 lM dopamine (h, dashed line).Modulation...
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Tài liệu Báo cáo khoa học: Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels pptx
... Cyclo-philin D binding decreased both ATP synthesis and hydrolysis rates. In the present study, we reaffirm these findings by demonstrating that, in intactmouse liver mitochondria energized by ATP, the ... [1,2], is of asufficient size (cut-off of $ 1.5 kDa) to allow the pas-sage of solutes and water, which may also result in rupture of the outer membrane. The identity of the proteins comprising the ... ablation of the ppif gene or inhibi-tion of CYPD binding on F0F1-ATP synthase bycyclosporin A led to a disinhibition of the ATPase,resulting in accelerated ATP synthesis and hydrolysisrates.However,...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... distribution,making them unsuitable for the investigation of b-cate-nin signalling [29]. In support of this aspect, usingMadin–Darby canine kidney cells that expressE-cadherin and b-catenin ... membraneproteins to migrate apically. Transcytosis of integrinswould therefore enable H. pylori with the intriguingpossibility of targeting the integrin b1receptor at api-cal membranes (Fig. 1). The ... Thus, the role of the CagL RGD-motif andCagY topology for injection of CagA is not yetresolved. It is also unclear why the effector proteinCagA itself can bind to the extracellular domain of inte-grin...
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Tài liệu Báo cáo khoa học: Kinetics of dextran-independent a-(1 fi 3)-glucan synthesis by Streptococcus sobrinus glucosyltransferase I pdf
... course of dextran-independent glucan synthesis We examined the kinetics of insoluble glucan synthesis from sucrose by GS and GSGB in the absence of dex-tran (Fig. 3A,B). For this purpose, we incubatedsucrose ... branches on the primer dextranbound to the C-terminal glucan-binding domain. We investigated the GTF-I-catalyzed glucan synthesis reaction in the absence of the primer dextran. The time course of saccharide ... glucan synthesis. The insoluble glucan synthesis reactionwas initiated by adding GSGB (filled squares) or GS (open squares)to the sucrose solution in the presence of dextran. The amount of insoluble...
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Từ khóa: báo cáo khoa học tài liệu báo cáo tài liệu báo cáo nghiên cứu khoa họctài liệu về báo cáo khoa họcbáo cáo khoa học tài chính côngBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Sở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015HIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ