... signaling [11], cardiovascular
diseases [12] and carcinogenesis [13]. The biogenesis
and RNAi functions of miRNA (i.e. how miRNAs are
generated and processed into a mature form, and how
they regulate ... a regulatory circuit and to maintain nor-
mal physiological functions. A disruption of this regulatory circuit may cause various diseases, such as cardiovascular diseases...
... Fragments and Text Categorization
Jan Bla
ˇ
t
´
ak and Eva Mr
´
akov
´
a and Lubo
ˇ
s Popel
´
ınsk
´
y
Knowledge Discovery Lab
Faculty of ... which consists
of fragments , . , such that and
. The value of depends
on the length of the document and on the number
of sentences in the fragments. Let ,
and denotes the set of possible classes. ... other languages, and also for the
frag...
... Carbohydrate,
glycolysis
Lactococcus
lactis
Modeling Pi explicitly and regulation
of pyruvate kinase (by Pi and FBP),
PFK (by PEP) and GAPDH (by
NADH) are critical to describe
observations (rapid increase in PEP,
Pi and gradual decrease ... metabolite
concentrations and metabolic fluxes,
both measured and nonmeasured. A
general parameter sensitivity
analysis is carried out to deter...
... H4-K5, K8
and K12 acetylation [136–138]. In yeast, this group is
made up of NuA4 and Piccolo NuA4 which both uti-
lize Esa1 as the HAT, and Esa1 was found to be essen-
tial for H4-K5, K8 and K12 ... acetylation and deacetyla-
tion, and transient recruitment of remodellers and
transcription factors.
A cycle of transcription commences with the recruit-
ment of transcription factor...
... tumors and cell lines, miR-17-
5p and miR-20a are induced in a manner that depends
on cyclin D1 and repress the expression of cyclin D1.
Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedback
loop and ... of
cell-cell signaling during development and disease. Cell
Cycle 7, 2327–2332.
11 Koh Ono YK & Jiahuai Han (2011) MicroRNAs and
cardiovascular diseases. FEBS J 278, 161...
... binding and cleav-
age by ribonuclease A and variants at Lys7, Arg10, and
Lys66. Biochemistry 37, 12121–12132.
31 Anderson DG, Hammes GG & Walz FG Jr (1968)
Binding of phosphate ligands to ... where I
i
(h) and I(h) are the ith and the mean
measurements of the intensity of reflection h, respectively. R
cryst
= R
h
|F
o
) F
c
| ⁄ R
h
F
o
, where F
o
and F
c
are the observed and...
... activation site (R144, N154, I152) and three in the
second (F127, M436 and H428), and found that Ap
4
A and ADP interact
with the same site, but the sites for ATP and BPG remain uncertain. The
structural ... cN-II, cN-III, cN-IA and cN-IB, and
both cytosolic and mitochondrial 5¢(3¢)-deoxyribonu-
cleotidases [5]. Even though all soluble 5 ¢-nucleotidases
share the same reaction...
... HPRT
and hypoxanthine. (C) PRTFDC1 and
guanine. (D) HPRT and guanine.
Table 2. K
m
and V
max
values for Hx and G in the presence of 1 mM PRPP, determined using the DE-81 filter paper assay and ... domain is mainly built
up by residues from the C-terminus and consists of a
two-stranded anti-parallel b-sheet composed of b2 and
b9 and an a-helix from the C-terminus (Fig. 1A). Th...
... ferre-
doxins, Fd1 and Fd2, from this bacterium are
considered to serve as low-potential electron donors
for this key reaction [8].
POR is distributed among archaea, bacteria and
anaerobic protozoa, and is ... phylogenetically related and the heterotetra-
meric enzyme has been proposed to be the common
ancestor that underwent gene rearrangement and
fusion to generate homo- and het...