... 34, 1497 5–1 4986.23. Due´e, E., Olivier-Deyris, L., Fanchon, E., Corbier, C., Branlant,G. & Dideberg, O. (1996) Comparison of the structures of wild-type and a N313T mutant of Escherichia ... mechanistic approach and the design of inhibitors such as 1,3-BPGA analogues far from easy.Indeed, the most potent and selective inhibitors of gGAPDH from parasites (T. brucei, Leishmania mexicana,T. ... residues 6 5–7 4,9 9–1 03 and 11 7–1 21 in monomer C and 9 9–1 02 inmonomer B and several residues at the N-terminus andC-terminus, which are poorly resolved. The stereochemistry of the structure is...