Tài liệu Báo cáo khoa học: Afﬁnity and kinetics of proprotein convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells docx

... [125I]TC-PCSK9 binding to HepG2 cells To determine whether the kinetics of binding of PCSK9 to HepG2 cells can be described as a simplebimolecular reaction, the kinetics of [125I]TC-PCSK9 and [125I]TC-PCSK9-D374Y ... 2011)doi:10.1111/j.1742-4658.2011.082 19. x Proprotein convertase subtilisin ⁄ kexin type 9 (PCSK9) is a secreted proteinthat regulates the number of cell surface low-density lipoprotein receptors (LDLRs) and the levels of low-density ... convertase subtilisin ⁄ kexin type 9 binding to low-density lipoprotein receptors on HepG2 cells Seyed A. Mousavi1, Knut E. Berge1, Trond Berg2 and Trond P. Leren11 Unit for Cardiac and Cardiovascular...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... six exons and ﬁve introns, stat6 wasfound to have 21 exons and 20 introns, and foxp3was found to have 13 exons and 12 introns. In thegenomic sequence, the intron splicing consensus(GT ⁄ AG) ... byTh1- and Th2 -type immunity [5]. Finally, in addition to Th cells, there is a population of CD4+T -cells thatis involved in the regulation of Th responses via thesecretion of cytokines, ... HJ, O’Garra A & Arai N ( 199 9) Ectopicexpression of activated Stat6 induces the expression of Th2-speciﬁc cytokines and transcription factors indeveloping Th1 cells. Immunity 11, 677–688.58...

Tài liệu Báo cáo khoa học: Molecular cloning and characterization of soybean protein disulﬁde isomerase family proteins with nonclassic active center motifs pdf

... & Perez-Grau L ( 198 9) Regu-lation of gene expression during plant embryogenesis.Cell 56, 1 49 160.15 Mu¨ntz K ( 199 8) Deposition of storage proteins. PlantMol Biol 38, 77 99 .16 Kamauchi S, ... of proteinfolding is accompanied by N-glycosylation and the for-mation of disulﬁde bonds [1]. Disulﬁde bonds areessential for structural stabilization and for regulation of the functions of ... http://www.phytozome.net/soy-bean#A). Comparison of the genomic sequences of GmPDIL-3a and GmPDIL-3b with those of the Ara-bidopsis and rice orthologs showed conservation of exon ⁄ intron structure...

Tài liệu Báo cáo khoa học: SREBPs: physiology and pathophysiology of the SREBP family ppt

... block binding of COPII proteins to SCAP, thereby controllingSCAP sorting in ER. Proc Natl Acad Sci USA 99 ,11 694 –11 699 .5 Horton JD & Shimomura I ( 199 9) Sterol regulatory ele-ment -binding ... transcription factor. Cell 89, 331–340.2 Brown MS & Goldstein JL ( 199 9) A proteolytic path-way that controls the cholesterol content of membranes, cells, and blood. Proc Natl Acad Sci USA 96 , ... channels are directtargets of SREBP.New aspects of SREBP functions To summarize, SREBP-1c is a physiological regulator of lipogenesis, and activation of SREBP couldcontribute to obesity-related pathophysiology...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of an R-Smad ortholog (SmSmad1B) from Schistosoma mansoni pdf

... schistosomes and to probe therole of SmSmad1B beyond its interaction with Sm-Smad4 and the formation of a Smad complex. Thetranscription factors p300 ⁄ CBP and GCN5 possess anintrinsic histone ... electrophoresis, and subjec-ted to autoﬂuorography as described above. To evaluate the effect of the presence of type I receptor(wild type or constitutively active) on the interaction of SmSmad2 and SmSmad4 ... consensus A ⁄ G ⁄ T-C ⁄ G-A ⁄ T-C ⁄ T-A ⁄ C ⁄ G-C ⁄ T) is also located [21].The DPE is known to act in conjunction with the Inrin the initiation of transcription. A potential AP-1(activator protein-1)...

Tài liệu Báo cáo khoa học: Topology, tinkering and evolution of the human transcription factor network doc

... Prendergast GC ( 199 9) New Myc-inter-acting proteins: a second Myc network emerges. Onco-gene 18, 294 2– 295 4.45 Zhang XK & Pfahl M ( 199 3) Hetero- and homodimeric receptors in thyroid hormone and vitamin ... & Davidson I (2002) RNA poly-merase II transcription in murine cells lacking theTATA binding protein. Science 298 , 1036–10 39. 42 Branden C & Tooze J ( 199 9) Introduction to ProteinStructure. ... the evolu-tion of TFs, and is discussed below.Functional, evolutionary and topologicalconstrainsBiological function of topological relevant elementsIn order to clarify the relation between...

Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx

... ( 199 9) Characterisation of granulocyte stimulation by thionins from European mis-tletoe and from wheat. Biochim Biophys Acta 1426,80 90 . 19 Edelhoch H ( 196 7) Spectroscopic determination of ... & Thompson CB ( 199 7) Bcl-xL regu-lates the membrane potential and volume homeostasis of mitochondria. Cell 91 , 627–637.27 Haugland RP ( 199 6) Handbook of Fluorescent Probes and Research ... sapecin: determination of membrane-buried and oligomerization surfaces by NMR. J Biol Chem 2 79, 498 1– 498 7.48 Vernon LP & Rogers A ( 199 2) Binding properties of Pyrularia thionin and Naja naja kaouthia...

Tài liệu Báo cáo khoa học: Puriﬁcation and characterization of glutamate N-acetyltransferase involved in citrulline accumulation in wild watermelon doc

... arelocalized in mitochondria [15,30,31], and ornithine isexported to the cytosol to be converted into citrulline and arginine [31,32]. In plants, information on thelocalization of citrulline and arginine ... thepuriﬁcation and characterization of GAT from wildwatermelon leaves, and discusses its function duringdrought ⁄ strong-light stress on the basis of its twounique enzymatic properties; thermotolerance ... regulations such as feedback inhibition and tran-scriptional regulation [8 ,9, 24]. In contrast, wild water-melon is unique for the massive accumulation of citrulline in the leaves in response to...

Tài liệu Báo cáo khoa học: The isolation and characterization of cytochrome c nitrite reductase subunits (NrfA and NrfH) from Desulfovibrio desulfuricans ATCC 27774 Re-evaluation of the spectroscopic data and redox properties ppt

... thedirect conversion of nitrite to ammonia in a six-electrontransfer reaction. It is a key enzyme involved in thesecond and terminal step of the dissimilatory nitratereduction pathway of the nitrogen ... 852, 288– 294 .30. Manchenko, G.P. ( 199 4) Handbook of Detection of Enzymes on Electrophoretic Gels pp. 86. CRC Press, Boca Raton, FL, USA.31. Fuhrop, J.H. & Smith, K.M. ( 197 5) In Laboratory Methods ... XXI/BD/113 49/ 97 (GA), PRAXIS XXI/BD/160 09/ 98 (SM) and PRAXISXXI/BD/15752 /98 (CAC), and by the COST working group.References1. Zumft, W.G. ( 199 7) Cell biology and molecular basis of denitri-ﬁcation....

Tài liệu Báo cáo khoa học: Puriﬁcation and characterization of a sialic acid speciﬁc lectin from the hemolymph of the freshwater crab Paratelphusa jacquemontii pdf

... sugars contribute to aremarkable diversity of sialyl epitopes in the sialoconjugates on the cell surface of neoplastic cells [11]. Human malignantmelanoma contains 9- O-acetyl-NeuAc [8,12] and in ... haemagglutination. On the other hand, human blood cells A, B and O [44,45], and sheep have surface glycoconjugates rich in NeuAc [44] and thereby the lectin showed poor binding afﬁnity towardsthese ... erythro-cytes.De-O-acetylated preparation of glycoproteins. De-O-acetylation of glycoproteins was performed following theprocedures of Sarris and Palade [30] and Schauer [6]. Asolution of 750 lL of glycoprotein...

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