... tumors and cell lines, miR-17-5p and miR-20a are induced in a manner that dependson cyclin D1 and repress the expression of cyclin D1.Hence, miR-17-5p ⁄ 20a and cyclin D1 form a feedbackloop and ... transcription factors E2F and Myc but,in turn, miR-17-92 downregulates the expression ofE2F and Myc [52]. In tumor progression, the tran-scription repressors ZEB1 and SIP1 and the miR-200family ... [60].By integrating mRNA and miRNA sequence and expression data with these comparative genomic data,we will be able to gain global, and yet specific, insightsinto the function and evolution of a broad...