... low(1-1.25 mg p.o. at night), increasing at approx-imately weekly intervals and according to clinical response.Nausea and vomiting are the commonest adverseeffects; these may respond ... levodopa. It became one of the mostwidely prescribed drugs for Parkinson's disease.Later clinical trials, however, failed to confirm theseeffects and indeed, combined treatment withlevodopa ... Parkinson'sdisease. It comes as no surprise, therefore, thatthese drugs can induce a state whose clinical features are very similar to those of idiopathicParkinson's disease. The...