... compounds and analytical database
84 Analysis of chemical warfare agents and their related compounds
Analysis of chemical warfare agents in human specimens
In the analysis of human specimens, the kinds ... estimating peaks appearing in the total ion chromatograms (TIC) using each RI value,
the same GC conditions and the n-alkane standards are adopted for the GC/MS an...
... MO, USA). Pure powder of perazine and clospi-
razine was donated by Mitsubishi Welpharma, Osaka, Japan; that of upentixol by Takeda
Chem. Ind. Ltd., Osaka, Japan; that of thioproperazine by ... Springer-Verlag Berlin Heidelberg 2005
II.3.1 Phenothiazines
by Akira Ishii and Yoshinao Katsumata
Introduction
Phenothiazine drugs, including chlorpromazine and levomepromazine, have...
... timiperone and spiperone with relatively high molecular weights,
LC/MS may be most suitable.
Poisoning cases, and toxic and fatal concentrations
A 2-year plus 5 month-old female and an 11-month-old male ... dyskinesia
of the face, appeared. us, diphenhydramine was injected into her intravenously; she recov-
ered 4 days a er admission. For the male baby, similar treatments, suc...
... antidepressants and carbamazepine obtained by
HPLC-UV. A: carbamazepine, B: desipramine, C: maprotiline, D: nortriptyline, E: amoxapine,
F: setiptiline, G: mianserin, H: imipramine, I: amitriptyline, ... 52:1190–1195 (in Japanese)
3) Tanaka E, Terada M, Nakamura T et al. (1997) Forensic analysis of eleven cyclic antidepressants in human biolo-
gical samples using a new reverse...
... Tanaka E, Nakamura T, Nagashima A et al. (2001) Determination of plasma bromvalerylurea and its main meta-
bolite by a simple high-performance liquid chromatographic method and quantitation of ... screening of drugs in biological
materials by gas chromatography and gas chromatography-mass spectrometry. A fatal poisoning by ingestion
of a drug containing acetaminophe...
... barbiturate
Case 1 [27]: a 40–45 year-old (estimated) female was found dead on a bed of a hotel. In her
room, 2 tablets of Vegetamin (a combined drug containing, phenobarbital, promethazine and ... GC and HPLC
are presented.
Incidence of fatal barbiturate poisoning cases. Since fatal cases due to Vegetamin® tablets
containing phenobarbital are many, its incidence rate is...
... phenytoin and carbamazepine-
epoxide can be purchased from Sigma. Lamotrigine, carbamazepine-diol and 9-hydroxy-
methyl-10-carbamyl acridan were reported to be obtainable from Chiba-Geigy (Basel, ... preparation
• Carbamazepine, ethosuximide, phenytoin, primidone, phenobarbital, diazepam, oxaze-
pam, nitrazepam and 5-( 4-methylphenyl )-5 -phenylhydantoin (internal standard, IS) can...
... uoroacetic acid can be added to a mobile
phase as an ion-pairing reagent for analysis of the quaternary amino muscle relaxants [6].
e) For solid-phase extraction of the drugs, weak cation-exchanger ... Dragendorff reagent;
➄
: iodoplatinate reagent
TLC analysis
362 Muscle relaxants
Direct inlet MS analysis [4]
Reagents and their preparation
• A 1-g aliquot of iodine and...
... β-receptors; they cause hypotension by decreasing the heart beat rate
and cardiac output, and prevent the attacks of arrhythmia and angina pectoris. In the brain, the
drugs attenuate migraine ... e β-blockers are structurally classi ed into isopropylamino drugs such as propranolol
and tertiary butylamino drugs such as nadolol; and many products containing 26 kinds of
β...
... for bleaching and other purposes. Sodium hypochlorite ( NaClO) aqueous solu-
tion is usually used as a disinfectant, bleaching agent, fungicide and ink eraser, and is thus
usually included in detergents ... solutions are analyzed by the above CE
to construct a calibration curve (concentration of a hypochlorite ion in a specimen vs. peak
area). A peak area obtained fro...